3 edition of Phase transitions in cell biology found in the catalog.
Includes bibliographical references and index.
|Statement||Gerald H. Pollack, Wei-Chun Chin, editors.|
|Contributions||Pollack, Gerald H., Jin, Weichun.|
|LC Classifications||QH581.2 .P43 2008|
|The Physical Object|
|Pagination||xi, 184 p. :|
|Number of Pages||184|
|LC Control Number||2008928026|
Many biomolecular condensates appear to form via spontaneous or driven processes that have the hallmarks of intracellular phase transitions. This suggests that a common underlying physical framework might govern the formation of functionally and compositionally unrelated biomolecular condensates. In this review, we summarize recent work that leverages a stickers-and-spacers framework adapted. Liquid-liquid phase separation in biology. Annu Rev Cell Dev Biol. ; PubMed. Kadavath H, Hofele RV, Biernat J, Kumar S, Tepper K, Urlaub H, Mandelkow E, Zweckstetter M. Tau stabilizes microtubules by binding at the interface between tubulin heterodimers. Proc Natl Acad Sci U S A. Jun 16;(24) Epub Jun 1 PubMed.
The visible outcome of liquid-liquid phase transitions (LLPTs) in cells is the formation and disintegration of various proteinaceous membrane-less organelles (PMLOs). Although LLPTs and related PMLOs have been observed in living cells for over years, the physiological functions of these transitions (also known as liquid-liquid phase separation, LLPS) are just starting to be understood. Self-organization, also called (in the social sciences) spontaneous order, is a process where some form of overall order arises from local interactions between parts of an initially disordered process can be spontaneous when sufficient energy is available, not needing control by any external agent. It is often triggered by seemingly random fluctuations, amplified by positive feedback.
Such mesoscopic phase transition can often be seen in soft-matter physics, where systems are driven by weak affinities. In a cell, a number of forces can affect molecular affinities, such as electrostatics or hydrogen bonds. Fine tuning these interactions could induce a similar demixing phase transition for other complexes. In contrast, the expression of p and cyclin A2 are reduced markedly when SAP is depleted. Therefore, a systems biology approach to analysing cell cycle transitions identifies the splicing protein, SAP as rate-limiting for the G 1 →S phase cell cycle transition but not for the transition .
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Phase Transitions in Cell Biology: Medicine & Health Science Books @ Phase Transitions In Cell Biology. Phase transitions occur throughout nature. The most familiar example is the one that occurs in water - the abrupt, discontinuous transition from a liquid to a gas or a solid, induced by a subtle environmental change.4/5(3).
About this book. About this book. Phase transitions occur throughout nature. The most familiar example is the one that occurs in water – the abrupt, discontinuous transition from a liquid to a gas or a solid, induced by a subtle environmental change.
Practically magical, the ever-so-slight shift of temperature or pressure can induce an astonishing transition from one entity to another entity that. Phase transitions occur throughout nature. The most familiar example is the one that occurs in water – the abrupt, discontinuous transition from a liquid to a.
On the reversible abrupt structural changes in nerve fibers underlying their excitation and conduction processes --Nonequilibrium phase transition in scattered cell communities coupled by auto/paracrine-like signalling --Interfacial water compartments on tendon/collagen and in cells --The role of ion-exchange on trypsin premature activation in.
Summary: Phase transitions occur throughout nature. The most familiar example is the one that occurs in water a" the abrupt, discontinuous transition from a liquid to a gas or a solid, induced by a subtle environmental change.
• Phase transitions are everywhere in nature, it may also be true in cell biology • Phase transition is switch-like – suitable for assembling structures on the go • Specific examples –[1D] Amyloid self-assembly –[2D] Two-component lipid membrane phase separation –[3D] Germ granule formation and localisation • Fundamental limits and nature’s solutions.
Abstract. Cell plasma membrane phaseplays a large role in membrane trafficking and signaling. The rolethat membrane phase plays in cell function, current hypothesesconcerning the size and time duration of the phase transitions, andthe role in disease are discussed.
The average phase behavior of a random mixture ensemble depends on both the width of the distribution of intermolecular interactions, σ, and the number of components, N. Condensation transitions dominate for large N and small σ, while demixing transitions are more likely in mixtures with fewer components and a broader distribution of interactions.
Phase separation is known to play a role in a variety of cellular processes, including formation of classical membraneless organelles, signaling complexes, the cytoskeleton, and numerous other supramolecular assemblies. However, in recent years, phase transitions have emerged as a novel form of cellular organization.
Phase transition is a physical process whereby a substance changes from one physical state to another. Examples are provided by the freezing of water into ice (liquid to solid) or the heating of water to generate water vapor (liquid to gas).
G 0 Phase. Not all cells adhere to the classic cell cycle pattern in which a newly-formed daughter cell immediately enters the preparatory phases of interphase, closely followed by the mitotic phase. Cells in G 0 phase are not actively preparing to divide.
The cell is in a quiescent (inactive) stage that occurs when cells exit the cell cycle. Phase transitions — changes between different states of organization in a complex system — have long helped to explain physics concepts, such as why water freezes into a solid or boils to become a gas.
How might phase transitions shed light on important problems in biological and ecological complex systems. The physics of phase transitions is an important area at the crossroads of several fields that play central roles in materials sciences. In this second edition, new developments had been included which came up in the states of matter physics, in particular in the domain of nanomaterials and atomic Bose-Einstein condensates where progress is accelerating.
Assembling recent research and theories, this book describes the phase and state transitions that affect technological properties of biological materials occurring in food processing and storage. Cell Symposia: Biological Assemblies: Phase Transitions and More POSTPONED – FURTHER DETAILS TO FOLLOW SHORTLY.
However, over the past few years a revolution in thought has been sweeping nearly the entire cell biology community. It is now becoming clear that many complex functions of the cell, and the multiple biochemical complexes that.
A combination of techniques from cell biology, biophysics, physical chemistry, structural biology, and bioinformatics are starting to help establish the molecular principles of an emerging field, thus paving the way for exciting discoveries, including novel therapeutic approaches for the treatment of age-related disorders.
Phase Transition. Synergetics: an Introduction, Nonequilibrium Phase Transitions and Self-organization in Physics, Chemistry, and Biology by H Haken (Author) ISBN ISBN Why is ISBN important. ISBN. This bar-code number lets you verify that you're getting exactly the right version or edition of a book.
The digit and digit. Membrane-bound p-Nephrin clusters through a phase transition upon addition of Nck and N-WASP. Nephrin is a transmembrane protein expressed in the foot processes of kidney podocyte cells, where its extracellular domain is a critical component of the slit diaphragm, the final element of the kidney's glomerular filtration barrier (Welsh and Saleem, ).
By analogy with the physicochemical phenomenon of gel-togel phase transition in synthetic chemistry (Tanaka et al., ;Hoffman, ;Annaka and Tanaka, ) and cell biology (Pollack. Phase Transitions in Cells CELL BIOLOGY Anthony A. Hyman and Kai Simons The organization of cellular compartments may be driven by liquid phase separations and the collective low-ﬁ nity interactions of macromolecules.
C ontemporary biology has identiﬁ ed many proteins involved in different cellular processes, but we are far. In the past few years the concept of protein phase transitions has taken the field of cell biology and protein biochemistry by storm.
The initial discoveries were met with great enthusiasm as they provide the rationale for the formation of membrane-less organelles, such as stress granules, processing bodies and RNP bodies, in biology and human disease. Although tools capable of reversibly triggering phase transitions in cells remain sparse, a promising optogenetic platform has been described (Cell–; ).